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Differin Adapalene Prescription Strength Retinoid Gel 0.1% Acne Treatment (Up to 90 Day Supply), 45 Gram

4.6 4.6 out of 5 stars 3,911 ratings

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  • Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
  • Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
  • In a clinical study, Differin gel provided up to 87 percent reduction in acne lesions after 12 weeks, which will continue to improve with further use

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From the manufacturer

differin gel, differin, acne treatment

differin, face cleanser, face moisturizer, lotion, retinoid, differin gel, moisture, oil control

Let’s be honest, at a certain age you’d rather have another breakup than another breakout. We feel like acne as an adult shouldn’t happen, but it does. Over 50 million Americans suffer from it annually. So, you’re not alone. But before you head into that board meeting sporting your three-piece suit and your latest breakout — it might be time to give Differin a try.

Differin Gel

Adapalene Gel 0.1% Acne Treatment

Differin contains the first OTC Rx-strength acne-fighting retinoid. Retinoids play a crucial role in the treatment of acne by regulating skin cell turnover & reducing inflammation deep in the skin to clear & prevent pimples. What makes the retinoid in Differin (Adapalene) so cool is that it’s gentler on your skin, while still effective — that means you get the clearer skin you want without having to do things like completely avoid sunlight forever!

How to get the most out of Differin Gel

differin, face cleanser, face moisturizer, lotion, retinoid, differin gel, moisture, oil control

differin, face cleanser, face moisturizer, lotion, retinoid, differin gel, moisture, oil control

differin, face cleanser, face moisturizer, lotion, retinoid, differin gel, moisture, oil control

differin, face cleanser, face moisturizer, lotion, retinoid, differin gel, moisture, oil control

Use a mild face wash, like Differin Daily Refreshing Cleanser, to remove surface oil and dirt without overly drying skin.

Then apply a thin layer of Differin Gel once every day all over your face — even when you’re not breaking out. Differin Gel might take a few weeks to start to work, and during this time, you could experience some dryness and irritation while your skin gets ready for gorgeous.

Keep skin protected all day with a hydrating SPF lotion like Differin Oil Absorbing Moisturizer, and soothed all night with a gentle moisturizer like Differin Soothing Moisturizer.

Clearer skin, eventually! The retinoid in Differin Gel may take a few weeks to work, and it may seem like it’s getting a little worse before it gets better. But, like your old track coach used to say, 'You just gotta push through it!'

Why use Differin

differin gel, differin, acne treatment

differin, face cleanser, face moisturizer, lotion, retinoid, differin gel, moisture, oil control

differin, face cleanser, face moisturizer, lotion, retinoid, differin gel, moisture, oil control

Beauty Favorite

In 2020 we won an Allure Best Of Beauty award, and in 2018 we won a Glamour Beauty Award. So we’re kind of a big deal.

Trust the process

This stuff isn’t like the other OTC products you’ve tried. There’s no true magic wand to get rid of a bad breakout, but Differin Gel renews skin from the inside out, resulting in clearer, smoother skin over time.

Before & after

When used every single day, Differin Gel can reduce up to 87% of acne in just 12 weeks (Cunliffe et al 1998, Galderma Laboratories). That’s about the time it would take to leisurely binge-watch your favorite old TV series.

Differin Products
Differin Gel Differin Gel Differin Gentle Cleanser Differin Soothing Moisturizer Differin Restorative Night Moisturizer Differin Dark Spot Correcting Serum
Differin Gel (15g) Differin Gel (45g) Differin Gentle Cleanser Differin Soothing Moisturizer Differin Restorative Night Moisturizer Differin Dark Spot Correcting Serum
Customer Reviews
4.5 out of 5 stars
78,487
4.5 out of 5 stars
1,697
4.4 out of 5 stars
2,290
4.6 out of 5 stars
7,582
Try Other Differin Products Clears and prevents pimples, blackheads, whiteheads and clogged pores to restore skin tone and texture. Up to a 30-day supply. Clears and prevents pimples, blackheads, whiteheads and clogged pores to restore skin tone and texture. Up to a 90-day supply. Gently removes makeup and other impurities, even on sensitive skin. Lightweight moisturizer for hydrated, healthy skin, with no greasy feel. Reduces appearance of redness from dryness and visibly improves skin texture by rehydrating skin overnight. Helps lighten post-acne marks, hyperpigmentation and blotches to improve overall skin tone and clarity.
Category Treat Treat Cleanse Moisturize Moisturize Correct
Size 15g 30-day supply 45g 90-day supply 4 oz 4 oz 2.5 oz 1 oz
Added benefit Contains the retinoid Adapalene Contains the retinoid Adapalene Great for sensitive skin Relieves dryness for 48-hour hydration Contains ceramides and hyaluronic acid With hydroquinone 2% to fade dark spots
Usage Once Daily, AM or PM Once Daily, AM or PM Daily AM and PM Daily AM or PM Daily PM Once Daily, AM or PM

Product Description

Differin Gel is the First New acne active ingredient available over the counter in over 30 years and is the First and strength retinoid acne treatment Now Available without a prescription. Differin Gel contains adapalene, a multi-benefit dermatologist recommended retinoid that clears and prevents acne, which helps restore skin’s natural tone and texture.

Product details

  • Is Discontinued By Manufacturer ‏ : ‎ No
  • Product Dimensions ‏ : ‎ 3.19 x 3.94 x 7.44 inches; 1.6 ounces
  • UPC ‏ : ‎ 302994910458
  • Manufacturer ‏ : ‎ Galderma Laboratories, Inc
  • ASIN ‏ : ‎ B01M114813
  • Customer Reviews:
    4.6 4.6 out of 5 stars 3,911 ratings

Important information

Indications

For the treatment of acne

Ingredients

Active ingredient: Adapalene 0.1% (retinoid) Inactive ingredients: carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water and sodium hydroxide. May contain hydrochloric acid to adjust pH.

Directions

Adults and children 12 years of age and older: - Use once daily - Clean the skin gently and pat dry before applying the product - Cover the entire affected area with a thin layer. For example, if your acne is on the face, apply the product to the entire face. - Do not use more than one time a day. Applying more than directed will not provide faster or better results, but may worsen skin irritation. Children under 12 years of age: ask a doctor. If pregnant or breast feeding, ask a doctor before use. Do not use Differin Gel if you are allergic to adapalene or any of the ingredients in the product.

Looking for specific info?

Customer reviews

4.6 out of 5 stars
4.6 out of 5
3,911 global ratings

Customers say

Customers like the quality, size and effect of the product. For example, they mention it works great, it's worth every dollar and that it helps improve general skin texture. That said, some complain about the durability, saying that it arrived damaged. Opinions are mixed on peeling and drying time.

AI-generated from the text of customer reviews

241 customers mention195 positive46 negative

Customers like the effect of the product on their skin. For example, they say it clears up nicely, improves texture, and helps with acne. Some say that it evens out skin tone and makes their skin brighter.

"...Now, five and a half months later, my pores are barely noticeable, my redness is all but gone, and I have ZERO breakouts for the first time in the..." Read more

"...and it calmed down the frequency/TENACITY of my breakouts, evened my skin texture, and helped a bit with the scaring...." Read more

"...I would recommend Differin to anybody wanting to see a huge improvement in hyperpigmentation (dark spots from acne past), acne breakouts, and uneven..." Read more

"...It took 2-3 weeks for it to really be noticeable, but my acne breakouts are all but gone. It is a life-changing difference...." Read more

182 customers mention151 positive31 negative

Customers like the quality of the product. They say it works great, is worth every dollar, and is good value for money. Customers also mention that the cleanser is great, the gel seems to be working, and the night moisturizer is long-lasting.

"...The Cetaphil was cheap (roughly $6 at Target) and it makes my skin soft and clean while the differin keeps the rosacea away...." Read more

"...I bought the differin night moisturizer, and it worked great (not too thick, and doesn’t smell)...." Read more

"...need a very tiny amount all over your face for it to be skin AND cost effective...." Read more

"...I started using them 4 days ago. The cleanser was great, the gel seems to be working, the night moisturizer is fabulous, too...." Read more

11 customers mention8 positive3 negative

Customers like the size of the product. They mention that it's significantly bigger than the small tube, and has a better price per oz. Some say that it makes their skin feel softer and their pores smaller. They also say that there is no scaling and that it takes a small amount to work.

"...Not one. If they do surface nowadays, they are small and manageable and are completely gone within 48 hours...." Read more

"...product was not improving my acne, it removed black heads, decreased the size of my pores, and got me smoother skin, so when the acne got back to..." Read more

"...The tube is small but you only need a pea sized amount. A little goes a long way!" Read more

"...It's significantly bigger than the small tube and is a better price per oz. I found that this product keeps any adult acne that may pop up away!..." Read more

88 customers mention35 positive53 negative

Customers are mixed about the drying time of the product. Some say that it's amazing and has smoothed out their skin texture. However, others say that they're very drying to the skin and it makes their face dry.

"...Be advised though, this is definitely not a moisturizer. You will absolutely need a moisturizer with this, regardless of skin type (mine is combo)...." Read more

"...After about roughly 2 weeks of use, my face stopped drying out, and the rosacea is just as minimized as when I was using the prescription foam...." Read more

"...It does make my skin pretty dry, especially during the initial "breaking in" period if I've stopped using it for a while...." Read more

"...The bumps are almost completely gone meaning my arms are smooth they don't feel like I have goosebumps anymore...." Read more

20 customers mention6 positive14 negative

Customers are mixed about the peeling of the product. Some mention that it doesn't over dry their skin, while others say that it made their skin so dry that it started peeling and was flaky.

"...I suffered from really sever redness, sensitivity, and peeling skin around my nose and mouth...." Read more

"...The purge for me was mainly severely dry skin, and flaking that wasn’t cute under makeup. Mostly around my nose and mouth...." Read more

"...I love how light it is, and I don't experience any peeling or side effects with this...." Read more

"...In the beginning I experienced really bad dryness, peeling, and burning of my skin...." Read more

14 customers mention3 positive11 negative

Customers are dissatisfied with the durability of the product. They mention that the box was ripped, the tube was dirty, and the product was damaged. Some customers also report that the product burns their skin and leaves flaky patches that won't go away. The box was obviously tampered with, and some customers say that it broke their face out.

"...First time I used it, I applied near my lips. Got a wound on the corner, where I applied it, and because of how dry my skin in that area got woth..." Read more

"Made me break out in tiny whiteheads under the skin all over, then some bigger blemishes...." Read more

"Works great I’ve used this before, however the box arrived damaged and squished. The tube was also squished" Read more

"...surface nowadays, they are small and manageable and are completely gone within 48 hours. I have not had a cyst in six weeks now...." Read more

Stick with it! It’s worth it!
5 Stars
Stick with it! It’s worth it!
Differin changed my life. I suffer from severe cystic acne on my cheeks, surface acne on my forehead and temples, large pores, rosacea, and hormonal acne around my jaw. I’ve tried every non-prescription product on the market with no resolution. Literally... EVERY PRODUCT. I started breaking out when I was about 12, and it’s been a battle ever since.I’ve been using differin for roughly five and a half months. I initially found it at a drug store, and figured “why not?” I had tried everything else, and was on the verge of consulting a dermatologist.The “purging” phase around weeks 4-6 was anything but awesome, but I stuck through it knowing that it was temporary, and that the acne that arose during that time was going to “pop up” regardless. Differin just made it happen all at once Instead of having random break out back to back. I suffered from really sever redness, sensitivity, and peeling skin around my nose and mouth. By week 10, most of my acne had greatly reduced, my pores seemed smaller, and the dry skin around my mouth and nose had resolved (I bought the night moisturizer, and it helped a ton!).Now, five and a half months later, my pores are barely noticeable, my redness is all but gone, and I have ZERO breakouts for the first time in the last 20 years.Before you buy differin, don’t expect instant gratification. Be aware that it’s a process, but if you stick through it, the results are worth it. Things WILL get worse before they get better (so I guess it’s a good thing we’re all wearing masks to cover our faces during the purging phase, right?). Be sure to use a really good night time moisturizer. I bought the differin night moisturizer, and it worked great (not too thick, and doesn’t smell). I also applied a light SPF moisturizer during the day. You will develop dry skin if you don’t moisturize, and there are times during the purging phase when your face will be sensitive to touch (but not overtly painful).Picture collage for progress:Upper left -Day ZeroUpper middle- Week 7Upper right - Week 14Bottom - Week 22(Top row is immediately after washing my face or using the product. Lower photo is the morning after using the product. This is without makeup!)No airbrushing/photo editing/or makeup have been used on any of these photos. My pores are TINY now and my redness is almost resolved. I initially went in hoping that it would clear up acne, but was pleasantly surprised that it also helped with pores and redness! I feel incredibly confident now, and never dreamed my skin would look this good.
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Top reviews from the United States

Reviewed in the United States on April 28, 2017
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5.0 out of 5 stars Works for rosacea, but took a while!
Reviewed in the United States on April 28, 2017
Ok, to begin, give this stuff about 2-3 weeks of use before judging it. Secondly, I use this for rosacea, not acne, so if you are looking to use it for that, keep reading.

I was diagnosed with rosacea about a year and a half ago. I get rough red bumps on my cheeks and forehead. They aren't super noticeable, but they make my skin not look as smooth and sometimes get worse depending on what I eat/drink. My dermatologist wrote me a prescription for Finacea foam, but the cost of it keeps going up. I was paying $240 a month for it. Rosacea is considered a cosmetic condition, not something detrimental to your health, so insurance doesn't help out a lot for the meds. Anyway, after getting sick of paying so much for a prescription, I started looking at other options. On a rosacea forum I saw a dermatologist recommend Differin and decided to try it. Here's my experience.

The first two weeks were hell. I put on Differin every night before bed and it would burn the heck out of my face. My cheeks would get redder, my skin would feel overly tight and almost like I had a sunburn, and the dryness was unstoppable. No matter how much lotion I put on my skin was constantly flaking.Then on top of that, from the constant lotion use I started to get pimples. I never get pimples. Ugh!! I honestly only "hung in there" out of desperation. After about roughly 2 weeks of use, my face stopped drying out, and the rosacea is just as minimized as when I was using the prescription foam. I am so thankful I stuck with this! I do not have to constantly slather on lotion, and my skin looks great. If I may suggest a tip though...use a good facial cleanser in the shower that smooths your skin. I started using Cetaphil in the shower on my face and it has done wonders in combination with the Differin. The Cetaphil was cheap (roughly $6 at Target) and it makes my skin soft and clean while the differin keeps the rosacea away.

I've attached a picture from this morning, after about 3 weeks of Differin use. It is a super close up so you can see how smooth my skin looks. Yes, I have a lot of pinkness in my cheeks still due to the rosacea, but I don't mind that...I only mind the gross bumps I get that make me look like Freddy Krueger.

I hope this review is helpful if you are suffering like I was. Best of luck to you on your journey to fight rosacea.
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117 people found this helpful
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Reviewed in the United States on July 8, 2020
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5.0 out of 5 stars Stick with it! It’s worth it!
Reviewed in the United States on July 8, 2020
Differin changed my life. I suffer from severe cystic acne on my cheeks, surface acne on my forehead and temples, large pores, rosacea, and hormonal acne around my jaw. I’ve tried every non-prescription product on the market with no resolution. Literally... EVERY PRODUCT. I started breaking out when I was about 12, and it’s been a battle ever since.

I’ve been using differin for roughly five and a half months. I initially found it at a drug store, and figured “why not?” I had tried everything else, and was on the verge of consulting a dermatologist.

The “purging” phase around weeks 4-6 was anything but awesome, but I stuck through it knowing that it was temporary, and that the acne that arose during that time was going to “pop up” regardless. Differin just made it happen all at once Instead of having random break out back to back. I suffered from really sever redness, sensitivity, and peeling skin around my nose and mouth. By week 10, most of my acne had greatly reduced, my pores seemed smaller, and the dry skin around my mouth and nose had resolved (I bought the night moisturizer, and it helped a ton!).

Now, five and a half months later, my pores are barely noticeable, my redness is all but gone, and I have ZERO breakouts for the first time in the last 20 years.

Before you buy differin, don’t expect instant gratification. Be aware that it’s a process, but if you stick through it, the results are worth it. Things WILL get worse before they get better (so I guess it’s a good thing we’re all wearing masks to cover our faces during the purging phase, right?). Be sure to use a really good night time moisturizer. I bought the differin night moisturizer, and it worked great (not too thick, and doesn’t smell). I also applied a light SPF moisturizer during the day. You will develop dry skin if you don’t moisturize, and there are times during the purging phase when your face will be sensitive to touch (but not overtly painful).

Picture collage for progress:
Upper left -Day Zero
Upper middle- Week 7
Upper right - Week 14
Bottom - Week 22
(Top row is immediately after washing my face or using the product. Lower photo is the morning after using the product. This is without makeup!)

No airbrushing/photo editing/or makeup have been used on any of these photos. My pores are TINY now and my redness is almost resolved. I initially went in hoping that it would clear up acne, but was pleasantly surprised that it also helped with pores and redness! I feel incredibly confident now, and never dreamed my skin would look this good.
Images in this review
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Customer image
47 people found this helpful
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Reviewed in the United States on July 27, 2022
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5.0 out of 5 stars Differin held my hand and told me everything was okay
Reviewed in the United States on July 27, 2022
I've been using Adapalene.1% (the active ingredient in Differin) since 2017ish. I struggled with acne scars causing hyperpigmentation spots. I was first given a topical cream by my primary care physician that helped calm major acne, but I was left with almost PURPLE scarring. Over the course of 5 years, I used Differin just about daily and it calmed down the frequency/TENACITY of my breakouts, evened my skin texture, and helped a bit with the scaring. I was so embarrassed to take pictures until my skin began to clear.

I pair this with benzoyl peroxide 4-5% wash and 1-4% for spot treatments when I feel acne coming up/treat breakouts. Benzoyl Peroxide and Adapalene are a dream team!

In the morning, I apply an occlusive moisturizer to protect my eye area that is prone to eczema, and then apply Differin to a wet face followed by a basic moisturizer and sunscreen. My skin at age 24 looks better than it did when I was 19! I experienced dryness and slow improvements the first 4ish months, and it wasn't until a full year later when my sister gasped when she noticed the absense of my spots.

Staying consistent, using a pea sized amount, and wearing sunscreen is key. You only need a very tiny amount all over your face for it to be skin AND cost effective. I've had periods of time in which I stopped using Adapalene in lieu of trying other trendy ingredients and noticed that my acne popped back up, not to the severity of how it once was, but enough to make me go BACK to Differin.

In the past month or so, I've been supporting Differin's anti-hyperpigmentation efforts by pairing it with Vitamin C in the morning, and not using it at night to use Faded by Topicals. I think I'll need another year to see the full results of that experiment, but I can always rely on Adapalene.1% to be there for me.
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7 people found this helpful
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